ZMIZ1 and estrogen receptor α form an essential partnership in endometrial biology

2025/11/30 by Md Saidur Rahman, Kyeong A So, Jae‐Wook Jeong · 1 voice
Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · Medicine · #Reproductive System and Pregnancy #Estrogen and related hormone effects #Endometriosis Research and Treatment

paper · doi:10.1172/jci199976

openalex publication_date 2025/11/30 · openalex created_date 2025/11/30 · openalex updated_date 2026/08/01

Abstract

Estrogen receptor α (ESR1) is a pivotal regulator of endometrial homeostasis and reproductive function, yet the coregulators that fine tune its transcriptional activity remain incompletely defined. In this issue of the JCI, Hewitt et al. identified Zinc finger MIZ-type containing 1 (ZMIZ1) as an ESR1 coregulator that is essential for stromal proliferation, decidualization, and overall endometrial integrity. ZMIZ1 deficiency was associated with endometriosis and endometrial cancer, and conditional ablation of Zmiz1 using the PgrCre mouse led to infertility and accelerated fibrosis due to impaired estrogen responsiveness. These findings position ZMIZ1 as a key modulator of estrogen signaling with translational potential as both a biomarker and a therapeutic target in uterine disorders.

Citations

• Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
• Native stem cell transcriptional circuits define cardinal features of high-risk leukemia
• Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial function

Discussions

• ZMIZ1 and estrogen receptor α form an essential partnership in endometrial biology: doi.org/10.1172/JCI1... This Commentary by Md Saidur Rahman, Kyeong A. So & Jae-Wook Jeong discusses Sylvia C. Hewi [bsky, 0 points, 0 comments]