2025/12/22 by J RAMOS, Paul R. Johnston, Robert J. H. Hammond +3 · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · #Mycobacterium research and diagnosis #Tuberculosis Research and Epidemiology #Genomics and Phylogenetic Studies
paper · doi:10.1099/acmi.0.001110.v2
openalex created_date 2025/12/22 · openalex publication_date 2025/12/22 · openalex updated_date 2026/07/14
Here we report the draft sequence of a rapid-growing nontuberculous Mycobacterium isolated from a urine sample at the Scottish Mycobacteria Reference Laboratory (SMRL), Royal Infirmary of Edinburgh, UK. The reported genome has a length of 6,749,454 bp, a GC content of 67.2%, and 6,336 protein-coding sequences. Average nucleotide identity (ANI) analysis identified Mycobacterium vanbaalenii PYR-1 as the closest relative (83.32% ANI), indicating that this isolate likely represents a novel species within the genus. Notably, phenotypic characterisation revealed a distinct antimicrobial resistance (AMR) profile. This assembly provides a valuable resource for studying the evolution of antimicrobial resistance mechanisms in nontuberculous mycobacteria and offers insight into resistance phenotypes observed in clinical isolates.