Endothelial-to-mesenchymal transition primes vascular endothelial cells toward an osteochondrogenic fate

2025/12/29 by Franceska Kishta, Ignacio Fernando Hall, Guanliang Li +10 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Angiogenesis and VEGF in Cancer #Congenital heart defects research #Single-cell and spatial transcriptomics

paper · doi:10.1016/j.vph.2025.107579

openalex created_date 2025/12/29 · openalex publication_date 2025/12/29 · crossref created 2025/12/29 · crossref issued 2026/03/01 · crossref published 2026/03/01 · crossref published-print 2026/03/01 · crossref deposited 2026/06/13 · crossref indexed 2026/06/13 · openalex updated_date 2026/08/01

Citations

• IL-1β and TGFβ2 synergistically induce endothelial to mesenchymal transition in an NFκB-dependent manner
• Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness
• Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases
• Single-cell transcriptional diversity is a hallmark of developmental potential
• Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis
• The changing landscape of atherosclerosis
• clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
• Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

Discussions

• New article: This study reveals that EndMT contributes to atherosclerosis by generating osteogenic- and chondrogenic-like cells, linking endothelial dysfunction to vascular calcification in disease #E [bsky, 0 points, 0 comments]