2023/09/25 by Zhenzhen Zhou, Chujun Liu, Yuting Guo +2 · 1 voice · 1 citation
Engineering · Materials Science · #3D Printing in Biomedical Research #Electrospun Nanofibers in Biomedical Applications #Innovative Microfluidic and Catalytic Techniques Innovation
paper · pdf · doi:10.1088/2631-7990/acfcf2
openalex publication_date 2023/09/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Abstract Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult, greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, as well as advanced tissue modeling.