Benzo[a]pyrene exacerbates atherosclerosis by upregulating SPP1 to promote macrophage inflammation and lipid dysregulation: An integrated network toxicology, RNA-seq, and experimental validation study

2026/02/25 by Runwen Li, Jieting Zheng, Yongjiang Tang +3 · 1 voice
Immunology and Microbiology · Medicine · #Alzheimer's disease research and treatments #Autophagy in Disease and Therapy #Immune cells in cancer

paper · doi:10.1016/j.vph.2026.107589

openalex created_date 2026/02/25 · openalex publication_date 2026/02/25 · crossref created 2026/02/25 · crossref issued 2026/03/01 · crossref published 2026/03/01 · crossref published-print 2026/03/01 · crossref deposited 2026/06/13 · crossref indexed 2026/07/13 · openalex updated_date 2026/08/01

Citations

• Role of Oxidative Modifications in Atherosclerosis
• PubChem 2023 update
• The Landscape of SPP1+ Macrophages Across Tissues and Diseases: A Comprehensive Review

Discussions

• Benzo[a]pyrene (BaP) worsens atherosclerosis via SPP1-driven macrophage inflammation and lipid dysregulation. Integrative omics with cellular validation reveal SPP1 as a potential target in pollution- [bsky, 0 points, 0 comments]