2025/01/01 by Hyo‐Jin Ro, Nam‐Hyuk Cho · 1 voice
Agricultural and Biological Sciences · Medicine · #Vector-Borne Animal Diseases #Viral Infections and Outbreaks Research #Viral Infections and Vectors
paper · pdf · doi:10.15212/zoonoses-2025-0005
openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
Severe fever with thrombocytopenia syndrome (SFTS), caused by the tick-borne severe fever with thrombocytopenia syndrome virus (SFTSV), is a disease that is endemic to East Asia and has mortality rates reaching 30%. Despite its substantial public health impact, no vaccines or antiviral treatments are currently available. The SFTSV genome encodes key structural proteins, including glycoproteins (Gn and Gc) and nucleocapsid protein (NP), which serve as critical vaccine targets. This Commentary reviews the current status of SFTSV-related vaccine platforms—such as viral vectors, inactivated viruses, DNA, mRNA, and protein-based approaches—and highlights the immune responses elicited by these platforms against key antigens, particularly glycoproteins and NP. Future research directions are additionally proposed to accelerate the development of effective SFTSV vaccines by leveraging insights from existing studies.