Hypoxia-responsive CEA-targeted CAR T cells in CEA-positive solid tumors through intraperitoneal or intravenous infusion: a phase 1 trial

2026/02/27 by Yang Gao, Jie Li, Hangyu Zhang +22 · 1 voice
Immunology and Microbiology · Medicine · #CAR-T cell therapy research #Immune Cell Function and Interaction #Monoclonal and Polyclonal Antibodies Research

paper · doi:10.1038/s43018-026-01124-3

crossref issued 2026/02/27 · crossref published 2026/02/27 · crossref published-online 2026/02/27 · openalex created_date 2026/02/27 · openalex publication_date 2026/02/27 · crossref created 2026/02/27 · crossref deposited 2026/04/29 · crossref indexed 2026/07/16 · openalex updated_date 2026/07/29

Citations

• Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
• Hypoxia-Responsive CAR-T Cells Exhibit Reduced Exhaustion and Enhanced Efficacy in Solid Tumors
• Safety and Efficacy of CT041 in Patients With Refractory Metastatic Pancreatic Cancer: A Pooled Analysis of Two Early-Phase Trials

Discussions

• 🚙 A Ju-Jitsu move with an automobile?: A CEA-targeted CAR-T only turned on in the hypoxic TIME doi.org/10.1038/s430... [bsky, 0 points, 0 comments]