Nintedanib Inhibits VEGF-Induced Neovascularization in Human Conjunctival Vascular Endothelial Cells

2025/09/15 by Yi Cheng, Tang-rui Huang, Yi-ke Yan +4 · 1 voice
Medicine · #Corneal Surgery and Treatments #Glaucoma and retinal disorders #Retinal Diseases and Treatments

paper · doi:10.1007/s11596-025-00114-3

crossref issued 2025/09/15 · crossref published 2025/09/15 · crossref published-online 2025/09/15 · openalex publication_date 2025/09/15 · crossref created 2025/09/15 · crossref published-print 2025/10/01 · openalex created_date 2025/10/10 · crossref deposited 2025/12/17 · crossref indexed 2026/07/10 · openalex updated_date 2026/07/23

Citations

• Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages
• Nintedanib: A Review in Fibrotic Interstitial Lung Diseases
• Vascular endothelial growth factor B-mediated fatty acid flux in the adipose-kidney axis contributes to lipotoxicity in diabetic kidney disease

Discussions

• This study reveals that #Nintedanib inhibits the #proliferation, migration, and #neovascularization of #Conjunctival #EndothelialCells by downregulating p-ERK and p-JNK in the #MAPK pathway. #medsky [bsky, 0 points, 0 comments]