2026/01/01 by Kanglin Li, Yifan Yang, Wenfeng Su +1 · 1 voice
Engineering · Medicine · #Bone Tissue Engineering Materials #Graphene and Nanomaterials Applications #Bone fractures and treatments
paper · doi:10.1515/ntrev-2025-0309
openalex publication_date 2026/01/01 · openalex created_date 2026/05/20 · openalex updated_date 2026/07/22
Abstract Research on nanotechnology for fracture healing is growing rapidly. A comprehensive bibliometric analysis of this field was still lacking. This study mapped the development trends and research hotspots. We collected articles and reviews on nanotechnology in fracture healing from 1995 to 2025. Data came from the Web of Science database. Bibliometric and visual analyses used VOSviewer, CiteSpace, and Sci Explorer. China published 359 papers, leading globally. The United States ranked second. India and Iran also contributed significantly. Chinese Academy of Sciences was the top institution. Soochow University and Sichuan University were highly productive. Neisiany Rasoul Esmaeely was the most prolific author. ACS Applied Materials & Interfaces published the most papers. Bioactive Materials had the highest impact. Five major research clusters emerged: bone regeneration, mechanical properties, in vitro studies, self-healing nanomaterials, and nanocoatings. Future hotspots include scaffolds, osteogenesis, and tissue engineering. Keyword burst analysis further suggested that delivery systems and tissue-engineering-based smart scaffolds may shape the next stage of this field, whereas clinical translation still faces challenges related to mechanical stability, degradation control, and complex pathological microenvironments. These findings help researchers understand the field and guide future studies.