Investigating DNA contamination affecting embryo biopsy specimens taken for PGT-A: Incidence and impact on the accuracy of chromosomal analysis

2026/02/20 by Georgina J. Clark, Georgina Clark, D Babariya +9 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Assisted Reproductive Technology and Twin Pregnancy #Genomic variations and chromosomal abnormalities #Prenatal Screening and Diagnostics

paper · doi:10.1016/j.rbmo.2026.105637

openalex created_date 2026/02/20 · openalex publication_date 2026/02/20 · crossref created 2026/02/20 · crossref deposited 2026/07/25 · crossref indexed 2026/07/25 · openalex updated_date 2026/07/27 · crossref issued 2026/08/01 · crossref published 2026/08/01 · crossref published-print 2026/08/01

Citations

• Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study
• On the reproductive capabilities of aneuploid human preimplantation embryos
• Concurrent Whole-Genome Haplotyping and Copy-Number Profiling of Single Cells

Discussions

• This study shows the value of using an appropriately validated PGT-A method that includes analyses of multiple polymorphisms - this strategy detects aneuploidy and chromosomal abnormality invisible to [bsky, 0 points, 0 comments]