2025/12/22 by Laura Gravelsins, Nicole J. Gervais, Alana Brown +6 · 1 voice
Medicine · Neuroscience · #Obstructive Sleep Apnea Research #Cerebrospinal fluid and hydrocephalus #Neuroscience of respiration and sleep
paper · doi:10.1080/13697137.2025.2595987
openalex created_date 2025/12/22 · openalex publication_date 2025/12/22 · openalex updated_date 2026/08/01
OBJECTIVE: There are many menopauses; bilateral oophorectomy is associated with the worst cognitive outcomes. Compared to females with intact ovaries, females with bilateral oophorectomy experience early, abrupt ovarian hormone loss and are at increased risk for later-life Alzheimer's disease. They also have double the odds of developing later-life sleep disordered breathing (SDB) - a modifiable Alzheimer's risk factor. With respect to bilateral oophorectomy, it is unknown when respiratory disturbances occur or whether estradiol therapy (ET) ameliorates them. Also unknown is whether SDB influences cognition in this group. METHOD: = 17) were assessed for SDB markers using take-home polysomnography and for working memory performance. RESULTS: The BSO group showed signs of respiratory disturbance compared to the AMC group. Memory performance was uncorrelated with respiratory metrics. While the BSO+ET group showed an intermediate sleep phenotype, estrone glucuronide levels correlated with improved respiratory metrics. CONCLUSION: The results suggest that respiratory disturbances manifest as early as 5 years post-BSO in younger females; ET offers some amelioration. The close relationship between sleep disruption and Alzheimer's risk emphasizes the importance of SDB screening post-BSO for early intervention.