Polyendocrine metabolic ovarian syndrome (PMOS)/polycystic ovary syndrome (PCOS): current and future trends

2026/06/14 by Jessica L. Chan, Irene Masini, Margareta D. Pisarska · 1 voice
Medicine · #Ovarian function and disorders #Hormonal and reproductive studies #Hormonal Regulation and Hypertension

paper · doi:10.1172/jci202824

openalex publication_date 2026/06/14 · openalex created_date 2026/06/15 · openalex updated_date 2026/07/31

Abstract

Polycystic ovary syndrome (PCOS), also known as polyendocrine metabolic ovarian syndrome (PMOS), is the most common endocrinologic disorder to affect women. Despite this, the pathophysiology of the disease is not entirely known. This has hindered the diagnosis of the disease and appropriate treatment for millions of individuals. In this Review, we discuss the proposed pathophysiology of PCOS from a translational perspective. We review the existing diagnostic criteria of PCOS and current management strategies. Finally, we discuss the long-term health sequelae associated with PCOS, future directions, and areas of needed research in this often-overlooked disease.

Citations

• New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins
• Prevention of moderate and severe ovarian hyperstimulation syndrome: a guideline
• Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming
• Single-cell profiling of the human endometrium in polycystic ovary syndrome
• Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process
• The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited

Discussions

• Review: Polyendocrine metabolic ovarian syndrome (PMOS)/polycystic ovary syndrome (PCOS): current and future trends: doi.org/10.1172/JCI2... Jessica L. Chan, Irene Masini & Margareta D. Pisarska disc [bsky, 0 points, 0 comments]