A novel naproxen potassium dihydrate: single-crystal structure and solid-state characterization of the dihydrate and its anhydrous form with improved dissolution properties

2026/01/01 by Marina Antonio, Gustavo Terrestre, Sebastian Andres Barolin +1 · 1 voice
Chemistry · Materials Science · #Crystallography and molecular interactions #Crystal structures of chemical compounds #X-ray Diffraction in Crystallography

paper · doi:10.1039/d6ce00184j

openalex publication_date 2026/01/01 · openalex created_date 2026/05/29 · openalex updated_date 2026/07/07

Abstract

Obtention and characterization of a novel salt of naproxen (NAP), a widely used nonsteroidal anti-inflammatory drug, exhibiting improved dissolution properties.

Citations

• EXPO2013: a kit of tools for phasing crystal structures from powder data
• Salt formation of two BCS II drugs (indomethacin and naproxen) with (1R, 2R)-1,2-diphenylethylenediamine: Crystal structures, solubility and thermodynamics analysis

Discussions

• "A novel naproxen potassium dihydrate: single-crystal structure & solid-state characterization of the dihydrate and its anhydrous form with improved dissolution properties" Cover article by M Antonio [bsky, 0 points, 0 comments]