Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches

2025/10/28 by Eleni V. Mikropoulou, Aikaterini Basdeki, Maria Halabalaki · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Metabolomics and Mass Spectrometry Studies #Traditional Chinese Medicine Analysis #Microbial Natural Products and Biosynthesis

paper · pdf · doi:10.1039/d5np00022j

openalex created_date 2025/10/28 · openalex publication_date 2025/10/28 · openalex updated_date 2026/07/14

Abstract

models have been developed to study the ADME properties of xenobiotics, while human clinical trials remain scarce in the field of NPs. Recent technological advancements, including innovations in mass spectrometry (MS), smart library screening, dereplication, molecular networking, and metabolomics, have significantly improved the NP research pipeline, offering faster and more accurate compound identification. High-resolution instruments like Orbitrap, QTOF, FT-ICR, and MRMS, alongside IMS and advanced data acquisition techniques (DDA and DIA), now offer deeper insights into complex mixtures. Despite MS being a cornerstone of pharmacokinetics-pharmacodynamics (PK/PD) studies, the integration of metabolomics and big data analytics remains underutilized, particularly in NP prioritization. This review aims to explore the evolution of MS in NP metabolism studies, from early investigations to current multidisciplinary approaches, proposing a critical reflection on the challenges in NP drug development.

Citations

• Pharmacokinetics of the soybean isoflavone daidzein in its aglycone and glucoside form: a randomized, double-blind, crossover study
• HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
• Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
• Natural products in drug discovery: advances and opportunities
• Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis
• Functional diversification of dietary plant small molecules by the gut microbiome
• Discovery and resupply of pharmacologically active plant-derived natural products: A review

Discussions

• 🔓Read this #OpenAccess review in our latest issue by Maria Halabalaki & co. from the University of Athens looking at metabolism and bioavailability aspects of plant natural products using mass spectr [bsky, 0 points, 0 comments]