2026/01/01 by Andrew J. Devine, Monserrat Manzo‐Ruiz, Catherine R. Back +4 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Enzyme Catalysis and Immobilization #Microbial Natural Products and Biosynthesis #Marine Sponges and Natural Products
paper · pdf · doi:10.1039/d6ob00728g
openalex publication_date 2026/01/01 · openalex created_date 2026/06/18 · openalex updated_date 2026/08/01
biotransformations. The X-ray crystal structure of ChlE3 reveals the molecular basis of decalin formation by this enzyme. Harnessing this enzymatic cascade in biocatalysis could provide a valuable biomimetic route to both natural and non-natural spirotetronates, and the work described herein lays the foundation for application of these enzymes in chemoenzymatic syntheses of complex products.