2026/06/08 by Lucas Greven, Stijn N.R. Fuchs, Hélène F.E. Gleitz +1 · 1 voice
Medicine · Immunology and Microbiology · #Myeloproliferative Neoplasms: Diagnosis and Treatment #Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis #Immune cells in cancer
paper · doi:10.1172/jci.insight.202062
openalex created_date 2026/06/08 · openalex publication_date 2026/06/08 · openalex updated_date 2026/08/01
Fibrosis affects almost all organ systems, resulting in a dysfunctional extracellular matrix that impairs function and can lead to failure. Crosstalk between immune cells and the stromal environment exacerbates fibrosis in all organs and is an attractive therapeutic target. Here, we discuss recent findings regarding the cellular and molecular mechanisms that underlie inflammation and fibrosis across organs. We focus on how reciprocal immune/stromal signaling maintains fibrotic niches, outline strategies for therapeutic intervention beyond current antifibrotic agents, and highlight the bone marrow fibrotic disease myelofibrosis as a model for understanding, and ultimately reversing, fibrosis in human disease.