2025/10/07 by Hua Tang, Yating Wu, Yuxi Wei +5 · 1 voice
Chemical Engineering · Chemistry · Engineering · #Analytical Chemistry and Sensors #Electrochemical sensors and biosensors #Molecular Sensors and Ion Detection
paper · doi:10.1021/acs.joc.5c01653
openalex publication_date 2025/10/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/13
A tetracationic macrocycle and a hexacationic cage bearing four and six pyridinium units, respectively, were synthesized via an S N 2 reaction in a one-pot manner. Both of these hosts have relatively rigid frameworks, containing several relatively acidic CH protons pointing inward. These hosts can recognize various anions such as chloride, bromide, iodide, and sulfate by leveraging a combination of hydrogen bonding and Coulombic attraction. Generally, the cage demonstrates enhanced association constants relative to the macrocycle, which has fewer binding sites.