1988/01/01 by Ji-lan Hu, JILAN HU, Yu-chuan Xue +11
Biochemistry, Genetics and Molecular Biology · Medicine · #Fungal Biology and Applications #Marine Sponges and Natural Products #Microbial Natural Products and Biosynthesis
paper · pdf · doi:10.7164/antibiotics.41.1575
crossref issued 1988/01/01 · crossref published 1988/01/01 · crossref published-print 1988/01/01 · openalex publication_date 1988/01/01 · crossref created 2012/03/01 · crossref deposited 2012/03/01 · openalex created_date 2025/10/10 · crossref indexed 2026/07/31 · openalex updated_date 2026/08/01
Strain C-1027, an actinomycete isolated from a soil sample collected in China, was found to produce the new antibiotic, C-1027. From taxonomical studies on its morphological, cultural and physiological characteristics, this antibiotic-producing strain was identified as Streptomyces globisporus C-1027. Antibiotic C-1027 has antimicrobial activity against most Gram-positive bacteria but not against Mycobacterium sp. or Gram-negative bacteria. This antibiotic shows remarkable activity in spermatogonial assay and potent cytotoxicity against KB carcinoma cells in vitro, and exhibits inhibition on transplantable tumors in mice.