The myxalamids, new antibiotics from Myxococcus xanthus (Myxobacterales) I. production, physico-chemical and biological properties, and mechanism of action.

1983/01/01 by Klaus Gerth, K. GERTH, Rolf Jansen +12 · 1 citation
Biochemistry, Genetics and Molecular Biology · Energy · Medicine · #Algal biology and biofuel production #Enzyme Catalysis and Immobilization #Microbial Natural Products and Biosynthesis

paper · pdf · doi:10.7164/antibiotics.36.1150

crossref issued 1983/01/01 · crossref published 1983/01/01 · crossref published-print 1983/01/01 · openalex publication_date 1983/01/01 · crossref created 2012/03/01 · crossref deposited 2012/03/01 · openalex created_date 2025/10/10 · crossref indexed 2026/07/31 · openalex updated_date 2026/08/01

Abstract

From the cell mass and culture supernatant of Myxococcus xanthus strain Mx X12 an antibiotic activity against yeasts, molds and some Gram-positive bacteria could be extracted. It consisted of 4 biologically active compounds which were named myxalamid A, B, C and D. The main component, myxalamid B, was shown to block in beef heart submitochondrial particles the respiratory chain at the site of complex I, i.e. NADH: ubiquinone oxidoreductase. The myxalamids are new antibiotics.

Cited by

• The Family Myxococcaceae