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Investigating the Genetic Basis of the Influence of Adiposity on Psoriasis: A Cross-Sectional Study in a Large United Kingdom Population–Based Biobank

2025/05/27 by Ravi Ramessur, Jake Saklatvala, Mari Løset +7 · 1 voice
Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #Psoriasis: Treatment and Pathogenesis #Digestive system and related health #Nutrition, Genetics, and Disease

paper · pdf · doi:10.1016/j.jid.2025.03.024

openalex publication_date 2025/05/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Psoriasis is a chronic inflammatory skin disease that has a substantial associated global public health burden (Griffiths et al, 2021). Adiposity is prevalent among individuals with psoriasis, particularly those with more severe disease, and evidence suggests a risk-increasing causal relationship between adiposity and psoriasis. First, increasing body mass index, waist circumference, and waist-to-hip ratio have been shown to be associated with increased psoriasis risk in large population-based studies (Snekvik et al, 2017).

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