Insulin resistance and the role of gamma-aminobutyric acid

2021/01/01 by Hossein Rezazadeh, Mohammadreza Sharifi, Nepton Soltani · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · #Adipose Tissue and Metabolism #Pancreatic function and diabetes #Metabolism, Diabetes, and Cancer

paper · doi:10.4103/jrms.jrms_374_20

openalex publication_date 2021/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15

Abstract

Insulin resistance (IR) is mentioned to be a disorder in insulin ability in insulin-target tissues. Skeletal muscle (SkM) and liver function are more affected by IR than other insulin target cells. SkM is the main site for the consumption of ingested glucose. An effective treatment for IR has two properties: An inhibition of β-cell death and a promotion of β-cell replication. Gamma-aminobutyric acid (GABA) can improve beta-cell mass and function. Multiple studies have shown that GABA decreases IR probably via increase in glucose transporter 4 (GLUT4) gene expression and prevention of gluconeogenesis pathway in the liver. This review focused on the general aspects of IR in skeletal muscle (SkM), liver; the cellular mechanism(s) lead to the development of IR in these organs, and the role of GABA to reduce insulin resistance.

Citations

• The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action
• Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models
• The Randle cycle revisited: a new head for an old hat
• Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle

Discussions

• 📄DOI: doi.org/10.4103/jrms... | A study found GABA may reduce insulin resistance, improving blood sugar control. #DiabetesCare #MetabolicHealth www.rimpacts.com/rd/p?c=10136... [bsky, 0 points, 0 comments]