Tetrazine- trans -cyclooctene ligated lanthanide conjugates for biomedical imaging

2025/10/13 by Hongxuan Chen, William Lim Kee Chang, Grace McMullon +8 · 1 voice
Chemistry · Biochemistry, Genetics and Molecular Biology · #Click Chemistry and Applications #Synthesis of Tetrazole Derivatives #Chemical Synthesis and Analysis

paper · pdf · doi:10.1039/d5qi01745a

openalex publication_date 2025/10/13 · openalex created_date 2025/10/25 · openalex updated_date 2026/08/01

Abstract

Tetrazine-functionalised lanthanide chelates and their catalyst-free ‘click’ reactions with a trans -cyclooctene-rhodamine fluorophore are reported. These probes were delivered across the blood–brain barrier using focused ultrasound and microbubbles.

Citations

• A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems
• Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions
• Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity
• Standards for photoluminescence quantum yield measurements in solution (IUPAC Technical Report)

Discussions

• Hot article by Nicholas J. Long 𝘦𝘵 𝘢𝘭. #ImperialCollegeLondon #ICL Authors report lanthanide complexation with a tetrazine‑functionalized DO3A chelator and subsequent tetrazine‑TCO ligation to a [bsky, 0 points, 0 comments]