2025/11/15 by Adam Kelly, Sourabh Sharma, Omar Mamlouk +18 · 1 voice
Medicine · #Chemotherapy-induced cardiotoxicity and mitigation #Chemotherapy-induced organ toxicity mitigation #Nephrotoxicity and Medicinal Plants
paper · doi:10.1093/ndt/gfaf251
openalex publication_date 2025/11/15 · openalex created_date 2025/11/18 · openalex updated_date 2026/07/27
Anticancer therapies have significantly improved survival rates in patients with cancer; however, despite prophylactic measures, many conventional chemotherapeutic agents cause acute and chronic kidney injury. This review provides a comprehensive analysis of the incidence, characteristics and management of platinum-based and antimetabolite chemotherapeutic agent-associated nephrotoxicity based on the existing literature. Understanding the profiles of these onconephrotoxic agents is essential for optimizing anticancer treatment while minimizing kidney complications.