Genenames.org: the HGNC and PGNC resources in 2026

2025/11/25 by Ruth L. Seal, Bryony Braschi, Kristian Gray +3 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Biomedical Text Mining and Ontologies #Genomics and Phylogenetic Studies

paper · pdf · doi:10.1093/nar/gkaf1229

openalex created_date 2025/11/25 · openalex publication_date 2025/11/25 · openalex updated_date 2026/08/01

Abstract

The HUGO Gene Nomenclature Committee (HGNC), based at the University of Cambridge, approves unique symbols and descriptive names for human genes. The HGNC database currently contains over 44 400 approved gene symbols, over 19 250 of which represent protein-coding genes, ∼14 500 represent pseudogenes, and over 9500 represent non-coding RNA genes. The public website, www.genenames.org, displays all approved nomenclature within manually curated Symbol Reports and also displays related groups of genes in Gene Group Reports. In 2024, we formed the Plant Gene Nomenclature Committee (PGNC), which has been approving gene symbols and names for the tree species Populus trichocarpa. All approved plant gene nomenclature is displayed on the new website plant.genenames.org. Here, we review updates to the HGNC project and introduce the PGNC project.

Citations

• Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse
• UniProt: the Universal Protein Knowledgebase in 2025
• Mutations in the small nuclear RNA gene RNU2-2 cause a severe neurodevelopmental disorder with prominent epilepsy
• A draft human pangenome reference
• Phytozome: a comparative platform for green plant genomics

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Discussions

• HGNC is pleased to announce that our latest NAR database paper is now live - see doi.org/10.1093/nar/... for HGNC updates and an introduction to the PGNC project [bsky, 0 points, 0 comments]