Regiodivergent gold( i )-catalysed rearrangements in indole synthesis

2025/11/12 by Ana K. García-Dueñas, Edson D. Hernández‐Velázquez, Jaime G. Ibarra‐Gutiérrez +6 · 1 voice
Chemistry · #Catalytic Alkyne Reactions #Catalytic C–H Functionalization Methods #Synthesis of Indole Derivatives

paper · doi:10.1039/d5qo01326g

openalex created_date 2025/11/12 · openalex publication_date 2025/11/12 · openalex updated_date 2026/08/01

Abstract

The gold( i )-catalysed [3,4]-sigmatropic rearrangement of 2-alkynyl anilines having electron-withdrawing benzylic groups, yield o -tolylindoles in a non-common methylene to methyl transformation.

Citations

• Gold-catalyzed heteroannulation and allyl migration: synthesis of highly functionalized indole derivatives

Discussions

• Recent article by César R. Solorio-Alvarado 𝘦𝘵 𝘢𝘭. Authors report a regiodivergent gold(I)-catalyzed cycloisomerization of 2-alkynyl anilines, affording C2-o-tolylindoles via [3,4]-sigmatropic re [bsky, 0 points, 0 comments]