2025/09/12 by Matías Pizarro, Ruben Gomez‐Gutierrez, Ariel Caviedes +6 · 2 voices
Medicine · Neuroscience · #Alzheimer's disease research and treatments #Cannabis and Cannabinoid Research #Tryptophan and brain disorders
paper · pdf · doi:10.18632/aging.206319
openalex publication_date 2025/09/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of misfolded proteins in the brain. Recently, the impact of blood components in the progression of this disease has come to attention. This study investigates the effects of infusing blood from young and old wild-type mice into transgenic mice that model AD brain amyloidosis. Impaired memory and Aβ accumulation were observed in mice infused with blood from old donors. A proteomic analysis in the brain of these mice identified alterations in components related to synaptogenesis and the endocannabinoid system. The α2δ2 protein, associated with neuronal calcium regulation, was validated as a possible mediator of the observed effects. This study highlights the influence of blood in AD pathology and the identification of potential therapeutic targets.