2025/12/12 by Matthew A.T. Elliott, John P. Andrews, Tjitse van der Molen +15 · 1 voice
Neuroscience · #Neural dynamics and brain function #Neuroscience and Neural Engineering #Neuroscience and Neuropharmacology Research
paper · doi:10.1152/jn.00217.2025
openalex created_date 2025/12/12 · openalex publication_date 2025/12/12 · openalex updated_date 2026/08/01
We apply high-density CMOS-based microelectrode arrays to excised patient brain slices, mapping the communication patterns of hundreds of neurons at unprecedented resolution. We developed novel computational techniques to spatially map neuronal dynamics. In patient slices, our findings suggest that recurrent feedback localized within the dentate gyrus of the hippocampus is linked to a previously unreported phenomenon of theta propagations. This bridges microscale circuit dynamics with alterations in theta oscillations.