Photocatalytic fluoroalkyl radical-initiated construction of fluorinated heterocycles: mechanisms and applications

2025/12/05 by Dandan Li, Long Chen, Zijia Xiong +3 · 1 voice · 1 citation
Chemistry · Materials Science · Pharmacology, Toxicology and Pharmaceutics · #Fluorine in Organic Chemistry #Photochromic and Fluorescence Chemistry #Radical Photochemical Reactions

paper · doi:10.1039/d5qo01484k

openalex created_date 2025/12/05 · openalex publication_date 2025/12/05 · openalex updated_date 2026/08/01

Abstract

This review highlights the strategy of photocatalytic fluoroalkyl radical-induced cyclization for synthesizing 5–7 membered fluorinated heterocycles.

Citations

• Metabolic and Pharmaceutical Aspects of Fluorinated Compounds
• Contribution of Organofluorine Compounds to Pharmaceuticals
• Current Contributions of Organofluorine Compounds to the Agrochemical Industry
• An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023)
• Understanding organofluorine chemistry. An introduction to the C–F bond

Cited by

• When Dowd–Beckwith reaction meets photocatalysis

Discussions

• This review consolidates progress since 2018, systematically dissecting the mechanisms of photocatalytic fluoroalkyl radical-driven formation of five-, six-, and seven-membered fluorinated heterocycle [bsky, 0 points, 0 comments]

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