2026/07/05 by Md Abu Bakr Siddique, Jakub Orłowski, Yan Zhang +1 · 1 voice
Computer Science · Engineering · Medicine · Neuroscience · #Advanced Memory and Neural Computing #Neurological disorders and treatments #Neuroscience and Neural Engineering #cs.AR #cs.NE
paper · pdf · doi:10.1145/3822454.3822465
arxiv published 2026/07/05 · arxiv updated 2026/07/05 · openalex created_date 2026/07/10 · openalex publication_date 2026/07/16 · openalex updated_date 2026/08/01
Parkinson’s disease (PD) affects millions worldwide and causes severe motor symptoms. Adaptive deep brain stimulation (aDBS) delivers physiologically informed stimulation that can track fluctuations in PD motor symptoms, enabling more intelligent DBS control. However, most existing aDBS approaches are primarily algorithm- and software-driven, with limited efforts toward circuit realization, particularly low-power and implantable integrated circuits. This paper presents the Silicon Leaky Integrate-and-Fire Deep Brain Stimulation (SiLIF-DBS) controller, a neuromorphic silicon neuron stimulator implemented with metal-oxide-semiconductor (CMOS) technology. For system-level evaluation, a simplified computational model of the SiLIF-DBS controller is derived and embedded within a Parkinsonian cortico-basal ganglia framework for closed-loop validation. The system is driven by beta-band subthalamic nucleus local field potentials (STN-LFPs), with their average rectified value (Beta ARV) used as the control biomarker. Our SiLIF-DBS controller for aDBS suppresses pathological beta activity while consuming only 25% of the power required by open-loop stimulation and achieving a suppression efficiency of \(5.85%\)/μ W. Overall, our SiLIF-DBS controller achieves strong beta suppression at substantially reduced power, delivering high suppression efficiency that demonstrates it is a viable foundation for low-power implantable aDBS.