2023/12/21 by Xiao-Ming Tao, Xiaoming Tao, Wei Liu +4
Medicine · #Adipokines, Inflammation, and Metabolic Diseases #Folate and B Vitamins Research #Nutrition and Health in Aging
paper · doi:10.1080/00207454.2023.2298374
openalex publication_date 2023/12/21 · crossref created 2023/12/21 · crossref issued 2024/02/03 · crossref published 2024/02/03 · crossref published-online 2024/02/03 · crossref deposited 2025/03/03 · crossref published-print 2025/03/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/08 · crossref indexed 2026/07/31
OBJECTIVE: To evaluate the diagnostic value of ultrasensitive C-reactive protein (hs-CRP) and homocysteine (Hcy) for cerebral infarction. METHODS: 260 elderly patients with cerebral infarction were recruited and assigned to the stroke group, and 60 healthy elderly were identified as controls and included in the normal group. Serum samples of all subjects were collected at the time of admission for the determination of hs-CRP and Hcy levels. RESULTS: Patients with cerebral infarction exhibited significantly higher hs-CRP and Hcy levels than healthy controls. the patients were then categorized into mild-moderate and moderate-severe groups according to the National Institutes of Health Stroke Scale (NIHSS) score. No significant association was identified between Hcy levels and infarction severity, while more severe infarction was potentially related to higher hs-CRP levels, as evidenced by the higher hs-CRP levels observed in patients with moderate-severe infarction versus a milder severity. Patients with disease recurrence within 2 years were also included in a recurrence group, while those without recurrence were in a non-recurrence group. Results showed that patients with or without disease recurrence had similar hs-CRP and Hcy levels. CONCLUSION: In elderly patients with cerebral infarction, serum hs-CRP, and Hcy levels are potentially promising markers for the diagnosis of stroke, assessment of stroke severity, and prediction of functional recovery. hs-CRP provides more benefits in diagnosing cerebral infarction, and Hcy is more conducive to the assessment of stroke severity and prediction of functional recovery. Combined detection of the two indices did not offer additional benefits in diagnostic and predictive efficacy.