A nonavalent BODIPY with a multivalent arrangement of α-mannosides enables lectins recognition in fluorescence-based assays

2025/12/05 by Giacomo Biagiotti, Edvin Purić, Jacopo Tricomi +8 · 1 voice
Materials Science · Chemistry · #Luminescence and Fluorescent Materials #Polydiacetylene-based materials and applications #Molecular Sensors and Ion Detection

paper · pdf · doi:10.1039/d5cb00190k

openalex created_date 2025/12/05 · openalex publication_date 2025/12/05 · openalex updated_date 2026/08/01

Abstract

dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and langerin, were further investigated. The approach proposed is versatile and paves the way for the development of multivalent and fluorescent glyco-BODIPY probes useful to interrogate carbohydrate-lectin interactions in different biological contexts.

Citations

• Identification of Different Binding Sites in the Dendritic Cell-specific Receptor DC-SIGN for Intercellular Adhesion Molecule 3 and HIV-1

Discussions

• 📢New research from B Richichi et al presents Tris-BODIPY-OH as a universal scaffold for glycosylated #FluorescentProbes showing improved affinity for target lectins useful for studying lectin traffic [bsky, 0 points, 0 comments]