2025/10/14 by Víctor Coca-Ruiz · 1 voice
Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · #Plant Pathogens and Fungal Diseases #Entomopathogenic Microorganisms in Pest Control #Fungal Plant Pathogen Control
paper · pdf · doi:10.3390/agrochemicals4040018
openalex created_date 2025/10/14 · openalex publication_date 2025/10/14 · openalex updated_date 2026/07/23
Modern agriculture faces a critical challenge from escalating fungicide resistance and the ecological impact of conventional agrochemicals. A paradigm shift is required, moving beyond simple product substitution toward an integrated technological platform. This review outlines such a platform, built on the synergy of three technologies: genome mining for rational discovery of novel antifungal compounds, synthetic biology for their scalable and cost-effective production, and RNA interference (RNAi) for highly specific pathogen control and resistance management. We argue that the integration of this trifecta—discovery, production, and targeted application—creates an adaptable pipeline for developing next-generation biofungicides. This approach transforms crop protection from a static defense to a dynamic, sustainable system capable of co-evolving with pathogens, ensuring future food security while minimizing environmental impact.