The Impact of Ancestry on Performance of Type 1 Diabetes Genetic Risk Scores: High Discrimination Performance Is Maintained in African Ancestry Populations, but Population-Specific Thresholds May Improve Risk Prediction

2026/01/16 by Steven Squires, Jean Claude Katte, Dana Dabelea +24 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #African american #Diabetes and associated disorders #Diabetes mellitus #Genetic Associations and Epidemiology #Genetic genealogy #MEDLINE #Pancreatic function and diabetes #Risk assessment #Risk factor #Type 1 diabetes

paper · pdf · doi:10.2337/dc25-1833

published in Diabetes Care 49(3), e33-e35 (American Diabetes Association)

crossref issued 2026/01/16 · crossref published 2026/01/16 · crossref published-online 2026/01/16 · openalex publication_date 2026/01/16 · crossref created 2026/01/16 · openalex created_date 2026/01/17 · crossref published-print 2026/03/01 · crossref deposited 2026/06/18 · crossref indexed 2026/06/18 · openalex updated_date 2026/08/01

Discussions

• We compared the performance of type 1 diabetes genetic risk scores (GRS) on diverse populations. One GRS showed good performance across ancestries, but high-risk thresholds might need to be varied. R [bsky, 0 points, 0 comments]