5,6-Fused heterocycle cholate derivatives as spore germination inhibitors of Clostridioides difficile

2026/02/02 by Shiv K. Sharma, Jacqueline R. Phan, Efren Heredia +2 · 1 voice
Agricultural and Biological Sciences · Medicine · #Clostridium difficile and Clostridium perfringens research #Gastrointestinal motility and disorders #Probiotics and Fermented Foods

paper · doi:10.1016/j.bmc.2026.118580

openalex publication_date 2026/02/02 · crossref created 2026/02/02 · openalex created_date 2026/02/03 · crossref issued 2026/04/01 · crossref published 2026/04/01 · crossref published-print 2026/04/01 · crossref deposited 2026/04/05 · openalex updated_date 2026/07/08 · crossref indexed 2026/07/23

Citations

• Clostridium difficile infection: review

Cited by

• Bile Acid Analogs with Anti-Germination Activities for Prophylaxis of Clostridioides difficile Infection Alter Bile Acid Homeostasis in the Enterohepatic Cycle

Discussions

• Novel 5,6-fused heterocycle cholate derivatives inhibited C. difficile spore germination — and one compound prevented infection in a murine model. Important translational work from WSU EACPHS. #Medi [bsky, 0 points, 0 comments]