2025/05/01 by Shiyan Cai, Xianghua Chen, Shulin Cao +7 · 1 voice
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Fungal Plant Pathogen Control #Mycotoxins in Agriculture and Food #Plant Pathogens and Fungal Diseases
paper · doi:10.1094/pdis-02-25-0244-re
openalex publication_date 2025/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Fusarium wilt (FW), caused by Fusarium oxysporum f. sp. lycopersici (Fol), is one of the most devastating diseases in tomato crops. None of the succinate dehydrogenase inhibitor (SDHI) fungicides is registered for the control of FW of tomatoes in China. In this study, the inhibitory activities of 12 SDHI fungicides against Fol were determined in vitro, and the results showed that pydiflumetofen and cyclobutrifluram exhibited excellent inhibitory activities, with inhibition rates of approximately 75.63 to 87.25% at a concentration of 1 μg ml −1 . Bixafen, fluopyram, isopyrazam, and benzovindiflupyr exhibited weak inhibitory activities, with inhibition rates of approximately 45.68 to 75.00% at a concentration of 20 μg ml −1 . Penflufen, sedaxane, isofetamid, boscalid, thifluzamide, and carboxin exhibited very poor inhibitory activities, with inhibition rates of approximately 13.45 to 61.73% at a concentration of 50 μg ml −1 . Forty pydiflumetofen-resistant mutants of Fol were obtained, and the point mutation of FoSDHC1 was associated with resistance of Fol to pydiflumetofen. Three FoSDHC1 deletion mutants were obtained, and FoSDHC1 deletion mutants exhibited no significant differences in vegetative growth, conidiation, and virulence but exhibited increased sensitivities toward all SDHI fungicides tested except thifluzamide and boscalid compared with the wild-type strain. These results indicated that FoSDHC1 regulated the sensitivity of Fol to most SDHI fungicides.