2021/09/13 by Ahmed A. Hawash, Giuseppe Ingrasci, Keyvan Nouri +1
Medicine · #Dermatologic Treatments and Research #Hair Growth and Disorders #Wound Healing and Treatments
paper · pdf · doi:10.2340/00015555-3923
openalex publication_date 2021/09/13 · crossref created 2021/09/13 · crossref issued 2021/10/28 · crossref published 2021/10/28 · crossref published-online 2021/10/28 · crossref deposited 2023/02/07 · openalex created_date 2025/10/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/30
Keloids are scars that extend beyond the margins of an insulting cutaneous injury. Keloids are often thought to be primarily a cosmetic issue, as they are typically quite raised and pigmented. However, these scars also present with functional symptoms of pruritus and pain that significantly impact quality of life. The symptom of pruritus is frequently overlooked by dermatologists, and treatments are often primarily focused on the gross appearance of the scar. This review describes the prevalence and importance of pruritus in keloids. In addition, the putative mechanisms underlying the development of keloid pruritus, which include neuronal and immunological mechanisms, are discussed. Furthermore, this review describes keloid treatments that have been shown to reduce pruritus, treatments that specifically target the itch, and emerging therapies.