2021/12/22 by Yueqi Qiu, Xingyu Zhou, Siqi Fu +2
Biochemistry, Genetics and Molecular Biology · Medicine · #Hair Growth and Disorders #Lipid metabolism and disorders #RNA regulation and disease
paper · pdf · doi:10.2340/actadv.v101.1012
openalex publication_date 2021/12/22 · crossref created 2021/12/22 · crossref issued 2022/02/08 · crossref published 2022/02/08 · crossref published-online 2022/02/08 · crossref deposited 2023/02/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29 · crossref indexed 2026/07/31
The association of androgenetic alopecia with metabolic syndrome has been investigated in several studies, with conflicting results. We conducted a meta-analysis to quantitatively evaluate the risk grade of metabolic syndrome and the metabolic profile in patients with androgenetic alopecia compared with controls. In total, 19 articles (2,531 participants) satisfied the inclusion criteria. The pooled odds ratio for the prevalence rate of metabolic syndrome between the group with androgenetic alopecia and controls was 3.46 (95% CI 2.38-5.05; p < 0.001). Female sex, early onset, and African ethnicity were associated with an increased risk of metabolic syndrome. Furthermore, patients with androgenetic alopecia had significantly poorer metabolic profiles, such as body mass index, waist circumference, fasting glucose, blood lipids, and blood pressure. It is important for physicians to screen metabolism-related indicators in patients with androgenetic alopecia. More rigorously designed studies and larger sample sizes are required in future studies.