1985/01/12 by Jonas Bergström, JONAS BERGSTRÖM, MARIANNE AHLBERG +3 · 1 citation
Medicine · #Erythropoietin and Anemia Treatment #Hemoglobinopathies and Related Disorders #Parathyroid Disorders and Treatments
paper · doi:10.1111/j.0954-6820.1985.tb01655.x
crossref issued 1985/01/12 · crossref published 1985/01/12 · crossref published-print 1985/01/12 · openalex publication_date 1985/01/12 · crossref published-online 2009/04/24 · crossref created 2010/08/15 · crossref deposited 2023/10/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28 · crossref indexed 2026/07/28
Glomerular filtration rate (GFR) by clearance of inulin and creatinine and effective renal plasma flow (ERPF) by para-aminohippurate clearance was investigated in 8 normal volunteers on low protein (LP) and high protein (HP) diet for 6 days in the basal state and after a mixed protein-rich test meal. Plasma immunoreactive insulin (IRI), glucagon (IRG) and growth hormone (IRHGH) were followed before and after the test meal. GFR was higher on HP than on LP diet and increased within one hour after the test meal. ERPF also increased significantly after the meal on LP diet. IRI increased maximally at 60 min after the test meal and then declined gradually. IRG increased after a latency period of 90 min and IRHGH consistently did not change. Since the increase in GFR was significant already one hour after the test meal, i.e. before IRG was changed, we conclude that glucagon is not a mediator of the protein-induced increased in GFR. Neither insulin nor growth hormone appeared to be involved.