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Low Urine Uromodulin Levels are Associated With Interstitial Fibrosis and Tubular Atrophy in Native Kidney Biopsies

2026/02/12 by Manav C. Parikh, Heather Thiessen Philbrook, Dajun Hu +8 · 1 voice
Medicine · #Chronic Kidney Disease and Diabetes #Kidney Stones and Urolithiasis Treatments #Chemotherapy-induced organ toxicity mitigation

paper · pdf · doi:10.1016/j.ekir.2026.106351

openalex publication_date 2026/02/12 · openalex created_date 2026/02/13 · openalex updated_date 2026/07/23

Abstract

Interstitial fibrosis and tubular atrophy (IFTA) is a critical histological feature assessed in kidney biopsies, with its severity strongly correlating with long-term clinical outcomes, including progression to end-stage kidney disease.1-3 Although kidney biopsy remains the gold standard for diagnosis and evaluating specific histological features such as IFTA, noninvasive methods to assess IFTA would be highly valuable for disease management, especially among patients with absolute or relative contraindications to biopsy.

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