2026/04/28 by Wisitsin Potiprapanpong, Parichart Naruphontjirakul, Naruporn Monmaturapoj +5 · 1 voice
Dentistry · #Dental materials and restorations #Endodontics and Root Canal Treatments #Dental Erosion and Treatment
paper · doi:10.2340/biid.v13.45796
openalex publication_date 2026/04/28 · openalex created_date 2026/04/29 · openalex updated_date 2026/06/11
Introduction: Resin-modified glass ionomer cements (RMGICs) exhibit lower remineralising potential than calcium-silicate (Ca-Si) cements. This study aimed to prepare an experimental RMGIC incorporating Sr/F-bioactive glass nanoparticles (EXP) to enhance remineralisation on demineralised dentine. The experimental material was compared with commercial Ca-Si cements (RetroMTA [MTA], Biodentine [BDT], Theracal LC [TC]) and a commercial RMGIC (Vitrebond [VB]). Materials and methods: Demineralised dentine specimens were attached to discs of each material and immersed in simulated body fluid for up to 4 weeks. Mineral precipitation was assessed using an Attenuated Total Reflection – Fourier Transform Infrared Spectroscopy (ATR-FTIR) and scanning electron microscopy-energy-dispersive X-ray spectroscopy analyses. Remineralisation was quantified as the mineral-to-collagen ratio, calculated from the phosphate FTIR peak height at 1024 cm-1 relative to the amide I peak at 1636 cm-1 (n = 5). Changes in pH and elemental release (Na, Al, Si, P, Ca and Sr) from materials immersed in deionised water over 4 weeks were also evaluated (n = 3). Indirect cytotoxicity of material extracts on human dental pulp stem cells was assessed using the 3-(4,5 dimethylthiazol-2-yl)-2,5-di-phenyltetrazolium bromide assay (MTT) assay (n=4). Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Tukey’s Honestly Significant Difference test. Results: The highest increase in the mineral-to-collagen ratio was observed with MTA (78%), which was significantly higher than that of VB (−28%) and EXP (−33%). Scanning electron microscopy analysis demonstrated mineral precipitation with MTA, BDT and TC but not with VB or EXP. Additionally, MTA, BDT and TC produced the highest alkalinisation of the storage solution (pH~12). EXP exhibited the release of multiple ions (Na, Al, Si, P, Ca and Sr). Although MTA showed the highest cell viability, all materials demonstrated cell viability exceeding 70%. Conclusion: The experimental RMGIC containing Sr/F-bioactive glass nanoparticles exhibited inferior remineralising potential compared with Ca-Si cements. However, it promoted the release of multiple essential ions.