Stirring the Debate: How Mixing Influences Reproducibility and Efficiency in Synthetic Organic Chemistry

2026/01/06 by Jasper H. A. Schuurmans, Stefan D. A. Zondag, Arnab Chaudhuri +2 · 1 voice
Engineering · Chemistry · Biochemistry, Genetics and Molecular Biology · #Innovative Microfluidic and Catalytic Techniques Innovation #Cyclization and Aryne Chemistry #Chemical Synthesis and Analysis

paper · pdf · doi:10.1021/acscentsci.5c01825

openalex publication_date 2026/01/06 · openalex created_date 2026/01/08 · openalex updated_date 2026/07/15

Abstract

Mixing is essential in chemical processes, ensuring the proximity and interaction of reactants. Recent reports suggest stirring may minimally affect some solution-phase organic reactions, but this oversimplifies mixing's complexity. We discuss its principles, relevance to organic synthesis, and practical considerations for reproducibility and safety. Even if some reactions seem agitation-insensitive, mixing remains crucial for reproducibility, scalability, and industrial applications.

Citations

• The Hitchhiker’s Guide to Flow Chemistry
• Enhancing electrochemical reactions in organic synthesis: the impact of flow chemistry
• Magnetic Stirring May Cause Irreproducible Results in Chemical Reactions
• Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology
• Flow Technology for the Genesis and Use of (Highly) Reactive Organometallic Reagents

Discussions

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