Association between Serum 25-Hydroxyvitamin D Levels and Skin Cancer Risk: An Observational Study Based on NHANES and Mendelian Randomization Analysis

2025/06/30 by Jinmiao Meng, Ruofei Du, P. P. Li +1 · 1 voice
Medicine · #Vitamin D Research Studies

paper · pdf · doi:10.14218/csp.2025.00010

openalex publication_date 2025/06/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11

Abstract

Skin cancer, the most common global malignancy, is linked to ultraviolet (UV)-driven serum 25-hydroxyvitamin D (25(OH)D)synthesis, with its controversial role possibly reflecting cumulative UV exposure. This study aimed to assess the association and causality between 25(OH)D levels and skin cancer risk using the National Health and Nutrition Examination Survey (1999–2018) data and Mendelian randomization (MR) analyses, evaluating 25(OH)D as a screening biomarker.

Discussions

• Serum 25(OH)D and skin cancer risk: NHANES observational study + Mendelian randomization. doi.org/10.14218/CSP... #SkinCancer @acscan.bsky.social [bsky, 0 points, 0 comments]

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