Tissue adaptation of eosinophils

2026/05/16 by Clotilde Marie Lacroix, Kalyani Kulkarni, Nicola Laura Diny · 1 voice
Immunology and Microbiology · #Immune responses and vaccinations #Immunodeficiency and Autoimmune Disorders #IL-33, ST2, and ILC Pathways

paper · doi:10.1093/jleuko/qiag064

openalex publication_date 2026/05/16 · openalex created_date 2026/05/19 · openalex updated_date 2026/07/31

Abstract

Eosinophils are increasingly recognized as tissue-resident immune cells that take on diverse functions. Recent studies have shed light on the pathways that result in tissue-specific eosinophil phenotypes. In this review, we discuss the process of tissue adaptation covering the local environmental cues that trigger adaptation, the transcriptional reprograming that occurs in response, and the phenotypic, metabolic, and functional adaptation that leads to varied eosinophil populations across the body. We further examine the relative impact of trained immunity and systemic factors versus local signals on eosinophil plasticity in the context of homeostasis and inflammation.

Citations

• Defining trained immunity and its role in health and disease
• Eosinophils respond to, but are not essential for control of an acute Salmonella enterica serovar Typhimurium infection in mice
• There’s no place like home: How local tissue microenvironments shape the function of innate lymphoid cells
• Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation
• Metabolically reprogrammed eosinophils impair T cell immunity and cause chronic skin infection
• Trained innate immunity: Concept, nomenclature, and future perspectives

Discussions

• Clotilde Lacroix, Kalyani Kulkarni & Nicola Diny @unibonn.bsky.social discuss the process of #TissueAdaptation that leads to varied #Eosinophil populations across the body [bsky, 0 points, 0 comments]

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