Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols

2023/09/11 by Paul W. Frazel, David Labib, Theodore Fisher +7 · 1 voice
Biochemistry, Genetics and Molecular Biology · Neuroscience · #MicroRNA in disease regulation #Neuroinflammation and Neurodegeneration Mechanisms #Single-cell and spatial transcriptomics

paper · doi:10.1038/s41593-023-01424-2

crossref issued 2023/09/11 · crossref published 2023/09/11 · crossref published-online 2023/09/11 · openalex publication_date 2023/09/11 · crossref created 2023/09/11 · crossref published-print 2023/10/01 · crossref deposited 2023/11/24 · openalex created_date 2025/10/10 · crossref indexed 2026/07/26 · openalex updated_date 2026/07/29

Citations

• RNA velocity of single cells
• Generalizing RNA velocity to transient cell states through dynamical modeling
• Integrated analysis of multimodal single-cell data
• Neuroinflammatory astrocyte subtypes in the mouse brain
• Neurotoxic reactive astrocytes induce cell death via saturated lipids
• Single-cell chromatin state analysis with Signac

Discussions

• I had a great experience today hearing students present a paper on cannabinoid receptor trafficking! Gave a brief introduction to epigenetics and am excited to see what they make of this behemoth of a [bsky, 1 points, 0 comments]