Principle and design of pseudo-natural products

2020/02/03 by George Karageorgis, Daniel J. Foley, Luca Laraia +1 · 1 voice · 4 citations
Biochemistry, Genetics and Molecular Biology · Computer Science · Medicine · #Chemical Synthesis and Analysis #Computational Drug Discovery Methods #Microbial Natural Products and Biosynthesis

paper · doi:10.1038/s41557-019-0411-x

crossref issued 2020/02/03 · crossref published 2020/02/03 · crossref published-online 2020/02/03 · openalex publication_date 2020/02/03 · crossref created 2020/02/03 · crossref published-print 2020/03/01 · crossref deposited 2023/09/26 · openalex created_date 2025/10/10 · crossref indexed 2026/07/24 · openalex updated_date 2026/07/29

Cited by

• Ring systems in natural products: structural diversity, physicochemical properties, and coverage by synthetic compounds
• De novo design and synthesis of Pseudo-natural products via multicomponent reactions: Discovery of antiviral compounds targeting host lipid droplets
• Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography
• Natural product drug discovery in the artificial intelligence era

Discussions

• The 2nd ChemBioChem/EFMC Joint Virtual Symposium is off to a great start with an amazing lecture by Herbert Waldmann. He talked about his group's groundbreaking work in the fields of biology oriented [bsky, 1 points, 2 comments]