Inhibiting quinolone biosynthesis of Burkholderia

2021/01/01 by Michaela Prothiwa, Verena Filz, Sebastian Oehler +1 · 1 voice
Agricultural and Biological Sciences · Energy · Medicine · #Burkholderia infections and melioidosis #Electrocatalysts for Energy Conversion #Insect symbiosis and bacterial influences

paper · pdf · doi:10.1039/d0sc06167k

openalex publication_date 2021/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Competitive profiling with a chemical probe against the central quinolone biosynthesis enzyme HmqD results in inhibitors that quantitatively block quinolone production in <italic>Burkholderia</italic> .

Discussions

• Amazing talk by Thomas Böttcher at the Two Days of Proteostasis. He talked about his group's many exciting projects on a chemist's perspective on host-microbe interactions. Great to see him highlight [bsky, 1 points, 0 comments]

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