Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells

2024/12/31 by Skylar S. Wright, P. Hima Kumari, Puja Kumari +16 · 1 voice · 4 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Heme Oxygenase-1 and Carbon Monoxide #Inflammasome and immune disorders #Streptococcal Infections and Treatments

paper · doi:10.1016/j.cell.2024.11.018

openalex publication_date 2024/12/31 · crossref created 2024/12/31 · crossref issued 2025/01/01 · crossref published 2025/01/01 · crossref published-print 2025/01/01 · openalex created_date 2025/10/10 · crossref deposited 2026/01/23 · openalex updated_date 2026/07/31 · crossref indexed 2026/07/31

Citations

• Overview of the <scp>IL</scp>‐1 family in innate inflammation and acquired immunity
• The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes
• Gasdermin E suppresses tumour growth by activating anti-tumour immunity
• Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Cited by

• One‐Step, Specific, and Fluorescent Sensing of pg‐Level TATP via Intramolecular Hydrogen Bond Breaking in Eu‐MOFs
• EMT and cancer: what clinicians should know
• Lipopolysaccharides Drive Proinflammatory Extracellular Vesicle Secretion in Coronary Artery Endothelial Cells via Noncanonical Inflammasome Activation
• Through the holes: the biotechnological potential of actinoporins (and other PFPs)

Discussions

• 📋 Pyroptotic cells release extracellular vesicles carrying gasdermin pores, which integrate into neighboring cells and propagate bystander pyroptosis, amplifying inflammation. 🗞️ Paper out now in @ [bsky, 1 points, 0 comments]