2025/02/19 by Deb Sankar Banerjee, Shiladitya Banerjee · 1 voice
Biochemistry, Genetics and Molecular Biology · Materials Science · #Enzyme Structure and Function #Microtubule and mitosis dynamics #Photosynthetic Processes and Mechanisms
paper · pdf · doi:10.7554/elife.92203.3
openalex publication_date 2025/02/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Accurate regulation of centrosome size is essential for ensuring error-free cell division, and dysregulation of centrosome size has been linked to various pathologies, including developmental defects and cancer. While a universally accepted model for centrosome size regulation is lacking, prior theoretical and experimental works suggest a centrosome growth model involving autocatalytic assembly of the pericentriolar material. Here, we show that the autocatalytic assembly model fails to explain the attainment of equal centrosome sizes, which is crucial for error-free cell division. Incorporating latest experimental findings into the molecular mechanisms governing centrosome assembly, we introduce a new quantitative theory for centrosome growth involving catalytic assembly within a shared pool of enzymes. Our model successfully achieves robust size equality between maturing centrosome pairs, mirroring cooperative growth dynamics observed in experiments. To validate our theoretical predictions, we compare them with available experimental data and demonstrate the broad applicability of the catalytic growth model across different organisms, which exhibit distinct growth dynamics and size scaling characteristics.