Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women

2025/01/07 by Virginia Nuckols, Leena N. Shoemaker, Andrew V. Kuczmarski +7 · 1 voice
Medicine · #Hormonal and reproductive studies #Thermoregulation and physiological responses #Urticaria and Related Conditions

paper · doi:10.1152/ajpheart.00815.2024

openalex publication_date 2025/01/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

The vascular endothelial endothelin-B receptor (ET B R) mediates vasodilation in premenopausal women, an effect modulated by estradiol. ET B R-mediated vasodilation is lost in postmenopausal women, but the effect of exogenous estradiol administration on ET B R function in postmenopausal women is not known. During estradiol administration, ET B R blockade did not affect cutaneous microvascular vasodilatory response to local heating. We demonstrate that exogenous estradiol administration does not restore ET B R-mediated vasodilation in postmenopausal women.

Discussions

• New AJP-Heart and Circ research published in the @apspublications.bsky.social Call for Papers on #WomensHealth and #HormoneReplacementTherapy & #Menopause demonstrates exogenous #estradiol administrat [bsky, 1 points, 0 comments]

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