Catalysis of an SN2 pathway by geometric preorganization

2024/07/18 by Gabriel J. Lovinger, Marcus H. Sak, Eric N. Jacobsen · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · #Protein Structure and Dynamics

paper · doi:10.1038/s41586-024-07811-4

crossref issued 2024/07/18 · crossref published 2024/07/18 · crossref published-online 2024/07/18 · openalex publication_date 2024/07/18 · crossref created 2024/07/18 · crossref deposited 2024/08/28 · crossref published-print 2024/08/29 · openalex created_date 2025/10/10 · crossref indexed 2026/07/29 · openalex updated_date 2026/08/04

Citations

• Über neue organische Phosphorverbindungen III. Phosphinmethylenderivate und Phosphinimine
• Independent gradient model based on Hirshfeld partition: A new method for visual study of interactions in chemical systems

Cited by

• Dual Activation Modes Enable Bifunctional Catalysis of Aldol Reactions by Flexible Dihydrazides
• Bifunctional Catalysis of Aldol Reactions by Foldamer Dihydrazides: Assessment of Conformational Preorganization

Discussions

• Our two other finalists were the Jacobson group's catalysis of an Sn2 by geometric preorganization (doi.org/10.1038/s41586-024-07811-4) (the mod's personal favorite) and the Reisman/Peters groups' rep [bsky, 1 points, 1 comments]